DelveInsight’s, \"Metastatic Renal Cell Carcinoma Pipeline Insights 2025\" report provides comprehensive insights about 40+ companies and 50+ pipeline drugs in Metastatic Renal Cell Carcinoma pipeline landscape. It covers the Metastatic Renal Cell Carcinoma pipeline drug profiles, including clinical and nonclinical stage products. It also covers the Metastatic Renal Cell Carcinoma therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.\n\nDiscover the latest drugs and treatment options in the Metastatic Renal Cell Carcinoma Pipeline. Dive into DelveInsight's comprehensive report today! @ Metastatic Renal Cell Carcinoma Pipeline Outlook\n\nKey Takeaways from the Metastatic Renal Cell Carcinoma Pipeline Report\nIn August 2025, Ontario Clinical Oncology Group (OCOG) conducted a phase II clinical trial evaluating SBRT as upfront cytoreductive therapy to the primary renal mass along with combination I/N therapy in patients with intermediate/poor risk mRCC who are not candidates for cytoreductive nephrectomy. Eligible and consenting, newly diagnosed and histologically confirmed intermediate/poor risk mRCC patients based on IMDC criteria with primary disease in-situ will be randomized in a 2:1 fashion to either induction I/N followed by SBRT prior to the second cycle (experimental arm) versus I/N alone (standard arm). Patients will be stratified based on IMDC criteria (intermediate 1-2 versus poor 3-6). DelveInsight’s Metastatic Renal Cell Carcinoma Pipeline report depicts a robust space with 40+ active players working to develop 50+ pipeline therapies for Metastatic Renal Cell Carcinoma treatment. The leading Metastatic Renal Cell Carcinoma Companies such as AstraZeneca, Genentech, Sumitomo Dainippon Pharma, Allogene Therapeutics, Nektar Therapeutics, Eli Lilly and Company, Xynomic Pharmaceuticals, AnewPharma, HUTCHMED, MedImmune, Incyte Corporation, NiKang Therapeutics, OncoC4, Inc., Nanobiotix, Aravive, Mirati Therapeutics Inc., BeiGene, Shanghai PerHum Therapeutics Co., Ltd., Akeso Biopharma, Novartis Pharmaceuticals, Vaccibody, SillaJen, Inc., Chongqing Precision Biotech Co., Ltd, Infinity Pharmaceuticals, Inc., SOTIO Biotech AG, Pfizer, Peloton Therapeutics, Inc., NeoTX Therapeutics Ltd and others. Promising Metastatic Renal Cell Carcinoma Therapies such as Cabozantinib, Pembrolizumab, Epacadostat, Sunitinib, BGB-A445, Tislelizumab, and others.\n\nStay ahead with the most recent pipeline outlook for Metastatic Renal Cell Carcinoma. Get insights into clinical trials, emerging therapies, and leading companies with DelveInsight @ Metastatic Renal Cell Carcinoma Treatment\n\nMetastatic Renal Cell Carcinoma Emerging Drugs Profile\nOlaparib: AstraZeneca\nOlaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2. PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Olaparib is used to treat a number of BRCA-associated tumours, including ovarian cancer, breast cancer, pancreatic cancer, and prostate cancer. It was first approved by the FDA and EU in December 2014. Currently, it is in Phase II stage of clinical trial evaluation to treat metastatic Renal Cell Carcinoma.\n\nAtezolizumab: Genentech\nAtezolizumab is a humanized IgG antibody that binds PD-L1, preventing its interaction with PD-1 and B7-1. Preventing the interaction of PD-L1 and PD-1 removes inhibition of immune responses such as the anti-tumor immune response but not antibody dependent cellular cytotoxicity. This medication is reserved for patients whose tumors express PD-L1, cannot receive platinum based chemotherapy, or whose tumors do not respond to platinum based chemotherapy. Atezolizumab was granted FDA approval on 18 October 2016. Currently, it is in Phase III stage of clinical trial evaluation to treat metastatic Renal Cell Carcinoma.\n\nTP-1454: Sumitomo Dainippon Pharma\nTP-1454 is an investigational oral pyruvate kinase M2 isoform (PKM2) activator, that is currently being evaluated in a Phase 1/1b study in patients with advanced metastatic or progressive solid tumors (NCT04328740). TP-1454 is the first PKM2 activator to be evaluated in cancer patients. Pyruvate kinase is the enzyme responsible for catalyzing the last step of glycolysis. PKM2 plays a critical role in the metabolic changes observed in cancer and immune cells and establishes a metabolic advantage for tumor cells over the tumor immune microenvironment.\n\nThe Metastatic Renal Cell Carcinoma pipeline report provides insights into\nThe report provides detailed insights about companies that are developing therapies for the treatment of Metastatic Renal Cell Carcinoma with aggregate therapies developed by each company for the same. It accesses the Different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Metastatic Renal Cell Carcinoma Treatment. Metastatic Renal Cell Carcinoma Companies are involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects. Metastatic Renal Cell Carcinoma Drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type. Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement and financing details for future advancement of the Metastatic Renal Cell Carcinoma market.\n\nExplore groundbreaking therapies and clinical trials in the Metastatic Renal Cell Carcinoma Pipeline. Access DelveInsight's detailed report now! @ New Metastatic Renal Cell Carcinoma Drugs\n\nMetastatic Renal Cell Carcinoma Companies\nAstraZeneca, Genentech, Sumitomo Dainippon Pharma, Allogene Therapeutics, Nektar Therapeutics, Eli Lilly and Company, Xynomic Pharmaceuticals, AnewPharma, HUTCHMED, MedImmune, Incyte Corporation, NiKang Therapeutics, OncoC4, Inc., Nanobiotix, Aravive, Mirati Therapeutics Inc., BeiGene, Shanghai PerHum Therapeutics Co., Ltd., Akeso Biopharma, Novartis Pharmaceuticals, Vaccibody, SillaJen, Inc., Chongqing Precision Biotech Co., Ltd, Infinity Pharmaceuticals, Inc., SOTIO Biotech AG, Pfizer, Peloton Therapeutics, Inc., NeoTX Therapeutics Ltd and others.\n\nMetastatic Renal Cell Carcinoma pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration\nInhalation Inhalation/Intravenous/Oral Intranasal Intravenous Intravenous/ Subcutaneous NA Oral Oral/intranasal/subcutaneous Parenteral Subcutaneous\n\nMetastatic Renal Cell Carcinoma Products have been categorized under various Molecule types such as\nAntibody Antisense oligonucleotides Immunotherapy Monoclonal antibody Peptides Protein Recombinant protein Small molecule Stem Cell Vaccine\n\nUnveil the future of Metastatic Renal Cell Carcinoma treatment. Learn about new drugs, pipeline developments, and key companies with DelveInsight's expert analysis @ Metastatic Renal Cell Carcinoma Market Drivers and Barriers\n\nScope of the Metastatic Renal Cell Carcinoma Pipeline Report\nCoverage - Global\nMetastatic Renal Cell Carcinoma Companies - AstraZeneca, Genentech, Sumitomo Dainippon Pharma, Allogene Therapeutics, Nektar Therapeutics, Eli Lilly and Company, Xynomic Pharmaceuticals, AnewPharma, HUTCHMED, MedImmune, Incyte Corporation, NiKang Therapeutics, OncoC4, Inc., Nanobiotix, Aravive, Mirati Therapeutics Inc., BeiGene, Shanghai PerHum Therapeutics Co., Ltd., Akeso Biopharma, Novartis Pharmaceuticals, Vaccibody, SillaJen, Inc., Chongqing Precision Biotech Co., Ltd, Infinity Pharmaceuticals, Inc., SOTIO Biotech AG, Pfizer, Peloton Therapeutics, Inc., NeoTX Therapeutics Ltd and others.\nMetastatic Renal Cell Carcinoma Therapies - Cabozantinib, Pembrolizumab, Epacadostat, Sunitinib, BGB-A445, Tislelizumab, and others.\nMetastatic Renal Cell Carcinoma Therapeutic Assessment by Product Type: Mono, Combination, Mono/Combination\nMetastatic Renal Cell Carcinoma Therapeutic Assessment by Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III\n\nGet the latest on Metastatic Renal Cell Carcinoma therapies and clinical trials. Download DelveInsight's in-depth pipeline report today! @ Metastatic Renal Cell Carcinoma Companies, Key Products and Unmet Needs\n\nTable of Content\nIntroduction\nExecutive Summary\nMetastatic Renal Cell Carcinoma: Overview\nPipeline Therapeutics\nTherapeutic Assessment\nMetastatic Renal Cell Carcinoma – DelveInsight’s Analytical Perspective\nLate Stage Products (Phase III)\nAtezolizumab: Genentech\nDrug profiles in the detailed report…..\nMid Stage Products (Phase II)\nOlaparib: AstraZeneca\nDrug profiles in the detailed report…..\nEarly Stage Products (Phase I)\nTP-1454: Sumitomo Dainippon Pharma\nDrug profiles in the detailed report…..\nPreclinical and Discovery Stage Products\nDrug name: Company name\nDrug profiles in the detailed report…..\nInactive Products\nMetastatic Renal Cell Carcinoma Key Companies\nMetastatic Renal Cell Carcinoma Key Products\nMetastatic Renal Cell Carcinoma- Unmet Needs\nMetastatic Renal Cell Carcinoma- Market Drivers and Barriers\nMetastatic Renal Cell Carcinoma- Future Perspectives and Conclusion\nMetastatic Renal Cell Carcinoma Analyst Views\nMetastatic Renal Cell Carcinoma Key Companies\nAppendix\n\nAbout Us\nDelveInsight is a leading healthcare-focused market research and consulting firm that provides clients with high-quality market intelligence and analysis to support informed business decisions. With a team of experienced industry experts and a deep understanding of the life sciences and healthcare sectors, we offer customized research solutions and insights to clients across the globe. Connect with us to get high-quality, accurate, and real-time intelligence to stay ahead of the growth curve.\n\nMedia Contact\nCompany Name: DelveInsight Business Research LLP\nContact Person: Yash Bhardwaj\nEmail: Send Email\nPhone: 09650213330\nAddress: 304 S. Jones Blvd #2432\nCity: Las Vegas\nState: NV\nCountry: United States\nWebsite: https://www.delveinsight.com/report-store/metastatic-renal-cell-carcinoma-mrcc-pipeline-insight\n\nPress Release Distributed by ABNewswire.com To view the original version on ABNewswire visit: Metastatic Renal Cell Carcinoma Pipeline Outlook Report 2025: Key 40+ Companies and Breakthrough Therapies Shaping the Future Landscape\n\nThis article contains syndicated content. 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Metastatic Renal Cell Carcinoma Pipeline Outlook Report 2025: Key 40+ Companies and Breakthrough Therapies Shaping the Future Landscape

DelveInsight's 2025 report provides a comprehensive analysis of the metastatic renal cell carcinoma (mRCC) pipeline, covering 40+ companies and 50+ pipeline drugs across various stages of development. The report details clinical and nonclinical drug profiles, including therapeutic assessments by product type, stage, route of administration, and molecular mechanism. It highlights key companies such as AstraZeneca, Genentech, Sumitomo Dainippon Pharma, and others, and outlines specific therapies like Olaparib, Atezolizumab, and TP-1454 in different clinical phases. The report also discusses ongoing clinical trials, including a phase II trial by the Ontario Clinical Oncology Group evaluating SBRT combined with I/N therapy for intermediate/poor risk mRCC patients. It includes information on inactive pipeline products and provides insights into collaborations, licensing, and financing strategies shaping the mRCC market.