Fractyl Health Inc is a metabolic therapeutics company focused on pioneering new approaches to the treatment of metabolic diseases, including type 2 diabetes and obesity. The company focuses on transforming metabolic disease treatment from chronic symptomatic management to durable disease modifying therapies that target the organ level root causes of T2D and obesity.

Fractyl Health, Inc. Common Stock

Fractyl Health is a leader in creating innovative therapies to address the root cause of type 2 diabetes. 

We were founded based on groundbreaking research and biological insights showing the key role of the intestine in metabolic control. Our therapies are uniquely designed to target and control this controller for the treatment of metabolic disease.

Our lead program, Revita DMR, is a first-in-class procedural therapy that is now in late-stage clinical trials for the treatment of type 2 diabetes.  

Our team is made up of passionate innovators at the intersection of biology and technology, working to deliver better real-world outcomes for people with metabolic disease. 

Fractyl is located in Lexington, Mass.  


General Catalyst

Bessemer Venture Partners

Catalio Capital Management

CDIB Ventures

Taiwania Capital Management Corporation

True Ventures

Mithril Capital Management

Google Ventures

Domain Associates

Emergent Medical Partners

Population Health Partners

M28 Capital

Maverick Capital

Fractyl Health

Fractyl Health announces new pooled analysis from our Revita® clinical studies demonstrating initial weight loss and sustained weight maintenance without weight regain through at least one-year post-Revita procedure. These new results, in over 100 human subjects from our controlled clinical studies, demonstrate that a single treatment with Revita can potentially enable sustained weight maintenance in people who are at risk of weight gain. https://lnkd.in/dKEAWd_r

We are thrilled to have presented preclinical findings from our Rejuva® gene therapy platform at the World Congress Insulin Resistance Diabetes and Cardiovascular Disease 2023 Annual Meeting. The oral presentation, titled “Single-dose GLP-1-based Pancreatic Gene Therapy Maintains Weight Loss After Semaglutide Withdrawal in a Murine Model of Obesity,” highlighted the promising implications of the Rejuva platform in providing a durable therapeutic solution for obesity with a GLP-1-based pancreatic gene therapy candidate (GLP-1 PGTx) designed to target the pancreas to provide long-term metabolic benefits from a single administration. #WCIRDC23 #T2D #obesity 

https://lnkd.in/eAKF-d_Z
maintained-weight-loss-after-semaglutide-withdrawal-in-a-murine-model-of-obesity/

*The Rejuva platform is in preclinical development and has not yet been evaluated by regulatory agencies for investigational or commercial use. 

We are excited to announce the expansion of an academic-industry scientific partnership charged with advancing research on the role of the gut and pancreas in metabolic disease. The new research, to be led by Professor Randy Seeley, Ph.D., at Michigan Medicine, is intended to explore the mechanistic rationale underlying the use of local pancreatic gene therapy to produce targeted treatment options that address, and hopefully remit, metabolic diseases. #T2D #obesity #type2diabetes #biotech #research #DiabetesAwarenessMonth https://lnkd.in/eEmyB_pe  

*The Rejuva platform is in preclinical development and has not yet been evaluated by regulatory agencies for investigational or commercial use. 

Today at #EASD2023, Dr. Harith Rajagopalan, Fractyl Health’s CEO, presented “Pancreatic Gene Therapy Durably Improves Glycemia and Delays Disease Progression in a Murine Model of Type 2 Diabetes.” 

Emphasizing new proof-of-concept data for Fractyl Health’s Rejuva® pancreatic gene therapy platform*, the presentation highlighted the promising implications of the Rejuva platform in potentially reshaping the treatment landscape for T2D and obesity with a GLP-1 based pancreatic gene therapy candidate (GLP-1 PGTx) designed to target the pancreas to provide long-term metabolic benefits from a single administration. The data presented corroborates the fundamental hypothesis that local delivery of a GLP-1 PGTx, driven by the insulin promoter, can potentially provide sustained weight loss after a single administration in obesity.  
 
The goal of Fractyl’s Rejuva platform is to develop gene therapy candidates that can durably change the trajectory of both obesity and T2D, and today’s results further consolidate preclinical proof-of-concept data for the viability of this approach. https://lnkd.in/ehUDdC6C #T2D #obesity #biotech #health #diabetes  
 
*The Rejuva platform is in preclinical development and has not yet been evaluated by regulatory agencies for investigational or commercial use.

COM:FRACTYL