Oculis Holding AG, a clinical-stage biopharmaceutical company, develops novel topical treatments for ophthalmic diseases for both back- and front-of-the-eye. The company's lead candidate is OCS-01, a topical dexamethasone formulation, which is in Phase 3 clinical trials for the treatment of diabetic macular edema; OCS-02, a topical biologic candidate that is in Phase 2b clinical trials for the treatment for keratoconjunctivitis sicca, or dry eye disease; and OCS-05, a novel neuroprotective agent for acute optic neuritis and other neuro-ophtha disorders, such as glaucoma, diabetic retinopathy, geographic atrophy, and neurotrophic keratitis. The company is based in Zug, Switzerland.

Oculis Holding AG

Beverly Hills Institute of Ophthalmology provides ophthalmology services including LASIK surgery, cataract surgery, and comprehensive eye care. The institute is described as having advanced technology and a team of experienced ophthalmologists.

Beverly Hills Institute of Ophthalmology

Grin Eye Care provides comprehensive eye care services, including cataract surgery, laser vision correction, and products like glasses and contacts. The company is self-described as dedicated to meeting all ophthalmology needs.

Grin Eye Care

SIEHT is a healthcare provider specializing in eye care services, including cataract surgery, LASIK vision correction, glaucoma treatment, and general eye exams.

SIEHT

Oculis is a global biopharmaceutical company purposefully driven to save sight and improve eye care. The company develops innovative product candidates for various eye conditions.

Oculis

Oculis (Nasdaq: OCS) is a global biopharmaceutical company purposefully driven to save sight and improve eye care. Oculis’ highly differentiated clinical-stage pipeline comprises multiple innovative product candidates in development for eye diseases of high unmet need. It includes OCS-01 eye drops, a topical candidate in Phase 3 development for diabetic macular edema (DME) and inflammation and pain following ocular surgery; OCS-02 eye drops, a topical biologic candidate in Phase 2 development for dry eye disease (DED) and uveitis; and OCS-05, a disease modifying candidate for acute optic neuritis (AON) and other neuro-ophthalmic disorders, such as glaucoma, diabetic retinopathy, geographic atrophy, and neurotrophic keratitis. The first in-patient, proof-of-concept trial with OCS-05 is currently ongoing in France. Headquartered in Switzerland and with operations in the US, Europe, and China, Oculis’ goal is to deliver life-changing eye treatments to patients worldwide. The company is led by an experienced management team with a successful track record in the pharmaceutical industry, supported by leading international healthcare investors.

Following our recent Phase 2 RELIEF data for licaminlimab (also known as OCS-02), our novel anti-TNFα antibody eye drop candidate, the Oculis team had the opportunity to attend the 2024 @European Dry Eye Society Congress (#EuDEC 2024). We enjoyed the opportunity to discuss the data, which delivered further evidence to support the potential of our #PrecisionMedicine approach for the treatment of dry eye disease (#DED), a growing area of unmet need that affects nearly 40 million people in the US alone. 
 
The RELIEF trial was an exploratory study designed to achieve three specific objectives: to evaluate the efficacy of licaminlimab on the signs of DED, to confirm the TNFR1 genetic biomarker as a predictor of response and to select the primary sign efficacy endpoint for a future Phase 3 trial. The trial met all three of these objectives, with positive topline data complementing two prior successful Phase 2 studies, during which the TNFR1 genetic biomarker was identified as a predictor of high responders to therapy. Excitingly, improvement of multiple signs of DED were observed in the full trial population, with more pronounced effect in the subpopulation with a TNFR1-related genotype, consistent with earlier trial results and laying the groundwork for progression towards a Phase 3 study. 
 
For more information on the RELIEF topline results including important information on forward-looking statements, see our press release here: ur press release here: https://bit.ly/4bWdQw0

EURETINA and Oculis have come together to pay a lasting tribute to Professor Tadayoni’s legacy. In this effort, EURETINA has established the Ramin Tadayoni Award supported by Oculis. 

Professor Tadayoni was a world-renowned retina specialist who contributed greatly to the field of ophthalmology and to Oculis’ success as Retina Chair of the company’s Scientific Advisory Board and as Chief Scientific Officer, at the time of his unexpected passing earlier this year.

Throughout his career, Professor Tadayoni was highly committed to advancing retinal research and education. This annual award will combine both of these profound values by supporting the next generation of talented ophthalmologists who have demonstrated outstanding potential in retinal research and are driving forward innovation in the field. 

For additional details on this announcement, see our press release here: https://bit.ly/4ezIZY9

For more information about the Ramin Tadayoni Award, including eligibility requirements and how to apply, visit: https://lnkd.in/eFgZen6f

#eyehealth #ophthalmology #biotech #biopharma #eyedisease #education #researchgrant

It was a privilege to join leading ophthalmology experts during Eyecelerator @ASCRS 2024, to discuss the treatment landscape and recent advancements that are accelerating innovation.

At Oculis, our innovative and diversified pipeline continues to advance, and we remain laser-focused on delivering our key programs: OCS-01 in DME, OCS-02 in DED and OCS-05 in Acute Optic Neuritis. We are confident and excited as we move into a catalyst-rich 2024 and look forward to updating everyone on the upcoming RELIEF trial readout planned by end of Q2 and  the ACUITY trial readout of OCS-05 in Acute Optic Neuritis planned in Q4.

Thank you again to the conference organizers for an excellent event!

#eyehealth #ophthalmology #biotech #biopharma #eyecelerator #ASCRS

We are thrilled to welcome industry leaders, @Robert K. Warner and Dr. Arshad M. Khanani, to our Board of Directors. Mr. Warner, who brings substantial global and U.S. commercial leadership expertise, and Dr. Khanani, a world-renowned retina expert, will be invaluable additions to our already strong Board as we progress toward important inflection points. Welcome to Oculis! 
 
For full bios and additional detail on Oculis’ Annual General Meeting, including important information on forward-looking statements, see our press release here: https://bit.ly/3VkeKwz
 
#eyehealth #ophthalmology #biotech #biopharma #eyedisease #leadership

Great article from Ghislaine Bloch in Bilan Magazine featuring Oculis and the progress made to date to fulfill our mission of saving sight and improving eye care

On Sunday, Eric Donnenfeld, M.D., presented the positive topline results from the Phase 3 OPTIMIZE-1 trial of OCS-01 for inflammation and pain following cataract surgery at the 2024 ASCRS Annual Meeting, which took place on April 5-8, 2024 in Boston, MA.
 
The Phase 3 OPTIMIZE-1 trial met its primary endpoints, demonstrating superior reduction in inflammation and pain vs. vehicle following cataract surgery. Topline data from the second Phase 3 OPTIMIZE-2 trial is anticipated in Q4 2024 and is expected to support NDA submission. If approved, OCS-01 would become the first once-daily, topical, preservative-free corticosteroid for treating inflammation and pain following ocular surgery. 
 
For additional details, including important information on forward-looking statements, see our press release here: https://bit.ly/3PTXbQV
 
#eyehealth #ophthalmology #biotech #biopharma #ASCRS

Metric
Company Name	Oculis Holding AG	Beverly Hills Institute of Ophthalmology	Grin Eye Care	SIEHT
Symbol	OCS
MSH ID	COM:OCULIS	COM:90210EYES	COM:GRINEYECARE	COM:SIEHT
Market	STOCKS	PRIVATE	PRIVATE	PRIVATE
Sector	Healthcare	Healthcare & Health Services	Healthcare & Health Services	Healthcare & Health Services
Industry	Biotechnology	Medical Services	Healthcare	Optometry
Country	CH	US	US	US
Stage
Employee Count	36		11
Website	oculis.com	90210eyes.com	grineyecare.com	sieht.com
LinkedIn	oculis-sa
Founders

Metric
Market Cap	467.04M
Enterprise Value
Monthly Web Traffic		3.26K	419
Web Traffic Growth		10.82	-0.85
Valuation
Raised Capital

Metric
Revenue	1.01M
Revenue (LTM)
Revenue (NTM)
Gross Profit	-32.33M
EBITDA	-52.12M
Operating Income	-52.27M
Net Income	-101.23M
EPS	-3.39
Diluted EPS	-3.39
Revenue 2022
Revenue 2023
Revenue 2024
Revenue 2025
Revenue 2026

Metric
Revenue Growth (LTM)
Revenue Growth (NTM)
Gross Profit Growth (LTM)
EBITDA Growth (LTM)
Net Income Growth (LTM)
14-Day Growth Score
28-Day Growth Score
90-Day Growth Score
365-Day Growth Score

Metric
Gross Profit Margin
Operating Profit Margin
EBITDA Margin	-51.78
Net Profit Margin
Return on Equity	-0.60
Return on Assets	-0.45
Return on Capital Employed	-0.49

COM:OCULIS

Oculis

Last Close

14.75

22/11 21:00

Market Cap

467.04M

Beta: -

Volume Today

39.61K

Avg: -

Company Overview

Market Metrics

Financial Performance

Growth Metrics

Profitability Ratios

Valuation Multiples

Operational Metrics

Cash Flow Metrics

Balance Sheet Metrics

Efficiency Metrics

Metric
P/E Ratio	-8.24
P/B Ratio	3.86
Revenue Multiple (LTM)
Revenue Multiple (NTM)
EBITDA Multiple (LTM)
EBITDA Multiple (NTM)
Price to Sales Ratio	857.01
EV Multiple	-7.67

Metric
Days Sales Outstanding
Days Payables Outstanding
Days Inventory Outstanding	16.66
Operating Cycle	1.37K
Cash Conversion Cycle	1.33K
Asset Turnover	0.01

Metric
Operating Cash Flow	-61.38M
Free Cash Flow	-61.43M
Cash Flow to Debt	-38.64
Operating Cash Flow/Sales
Free Cash Flow Yield	-0.07

Metric
Cash & Equivalents	43.69M
Accounts Receivable
Inventory
Goodwill
Debt to Capitalization	0.01
Debt to Assets	0.01
Current Ratio	5.21
Quick Ratio	5.27

Metric
Rule of 40 (LTM)
Rule of 40 (NTM)
Stock Comp to Revenue
R&D to Revenue
SG&A to Revenue