Silence Therapeutics plc focuses on the discovery, development, and delivery of novel RNA therapeutics in hematology, cardiovascular, and other rare and metabolic indications. The company designs short interfering RNA (siRNA) molecules that trigger the RNAi pathway and mediate the degradation of specific target messenger RNAs. It is developing various product candidates, including SLN124 for the treatment of iron overload disorders; SLN360 for the cardiovascular disease with high lipoprotein; and SLN500 for the treatment of complement-mediated diseases. Silence Therapeutics plc has a strategic collaboration with AstraZeneca to discover, develop, and commercialize small interfering RNA therapeutics for the treatment of cardiovascular, renal, metabolic, and respiratory diseases; and collaboration with Genomics England Limited. The company was formerly known as SR Pharma plc and changed its name to Silence Therapeutics plc in May 2007. Silence Therapeutics plc is headquartered in London, the United Kingdom.

Silence Therapeutics plc

Alnylam Pharmaceuticals, Inc., a biopharmaceutical company, focuses on discovering, developing, and commercializing novel therapeutics based on ribonucleic acid interference. The company's pipeline of investigational RNAi therapeutics focuses on genetic medicines, cardio-metabolic diseases, hepatic infectious diseases, and central nervous system (CNS)/ocular diseases. Its marketed products include ONPATTRO (patisiran), a lipid complex injection for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults; GIVLAARI for the treatment of adults with acute hepatic porphyria (AHP); and OXLUMO (lumasiran) for the treatment of primary hyperoxaluria type 1 (PH1). In addition, the company is developing givosiran for the treatment of adolescent patients with AHP; patisiran for the treatment of transthyretin amyloidosis, or ATTR amyloidosis, with cardiomyopathy; cemdisiran to treat complement-mediated diseases; ALN-AAT02 for the treatment of AAT deficiency-associated liver disease; ALN-HBV02 to treat chronic HBV infection; Zilebesiran to treat hypertension; and ALN-HSD to treat NASH. Further, it offers Fitusiran for the treatment of hemophilia and rare bleeding disorders, Inclisiran to treat hypercholesterolemia, lumasiran for the treatment of advanced PH1 and recurrent renal stones, and vutrisiran for the treatment of ATTR amyloidosis, which is in phase 3 clinical trial. Alnylam Pharmaceuticals, Inc. has strategic collaborations with Regeneron Pharmaceuticals, Inc. to discover, develop, and commercialize RNAi therapeutics for a range of diseases by addressing therapeutic targets expressed in the eye and CNS; and Sanofi Genzyme to discover, develop, and commercialize RNAi therapeutics. It also has license and collaboration agreements with Novartis AG; Vir Biotechnology, Inc.; Dicerna Pharmaceuticals, Inc.; Ionis Pharmaceuticals, Inc.; and PeptiDream, Inc. The company was founded in 2002 and is headquartered in Cambridge, Massachusetts.

Alnylam Pharmaceuticals, Inc.

Silence Therapeutics develops siRNA-based medicines targeting genetic diseases, focusing on hematology, cardiovascular disease, and rare diseases, based on its mRNAi GOLD™ platform.

Metric
Company Name	Silence Therapeutics plc	Alnylam Pharmaceuticals, Inc.
Symbol	SLN	ALNY
MSH ID	COM:SILENCE-THERAPEUTICS	COM:ALNYLAM
Market	STOCKS	STOCKS
Sector	Healthcare	Healthcare
Industry	Biotechnology	Biotechnology
Country	GB	US
Stage
Employee Count	65	2.10K
Website	silence-therapeutics.com	alnylam.com
LinkedIn
Founders

Metric
Market Cap		32.60B
Enterprise Value
Monthly Web Traffic	1.56K	55.97K
Web Traffic Growth	2.82	0.89
Valuation
Raised Capital	120M	900M

Metric
Revenue		1.83B
Revenue (LTM)
Revenue (NTM)
Gross Profit		1.52B
EBITDA		-228.12M
Operating Income		-282.18M
Net Income		-440.24M
EPS		-3.52
Diluted EPS		-3.52
Revenue 2022
Revenue 2023
Revenue 2024
Revenue 2025
Revenue 2026

Metric
Revenue Growth (LTM)
Revenue Growth (NTM)
Gross Profit Growth (LTM)
EBITDA Growth (LTM)
Net Income Growth (LTM)
14-Day Growth Score
28-Day Growth Score
90-Day Growth Score
365-Day Growth Score

Metric
Gross Profit Margin		0.87
Operating Profit Margin		0.04
EBITDA Margin		-0.12
Net Profit Margin		-0.03
Return on Equity		1.67
Return on Assets		-0.02
Return on Capital Employed		0.03

COM:SILENCE-THERAPEUTICS

Silence Therapeutics

Last Close

540.00

01/01 00:00

Volume Today

913.53K

Avg: -

Company Overview

Market Metrics

Financial Performance

Growth Metrics

Profitability Ratios

Valuation Multiples

Operational Metrics

Cash Flow Metrics

Balance Sheet Metrics

Efficiency Metrics

Metric
P/E Ratio		-42.10
P/B Ratio		-129.43
Revenue Multiple (LTM)
Revenue Multiple (NTM)
EBITDA Multiple (LTM)
EBITDA Multiple (NTM)
Price to Sales Ratio		16.84
EV Multiple		326.32

Metric
Days Sales Outstanding		68.92
Days Payables Outstanding		97.72
Days Inventory Outstanding		128.53
Operating Cycle		187.09
Cash Conversion Cycle		104.98
Asset Turnover		0.58

Metric
Operating Cash Flow		104.16M
Free Cash Flow		41.95M
Cash Flow to Debt		0.15
Operating Cash Flow/Sales		0.16
Free Cash Flow Yield		-0.00

Metric
Cash & Equivalents		812.69M
Accounts Receivable		-87.94M
Inventory		89.15M
Goodwill
Debt to Capitalization		1.20
Debt to Assets		0.34
Current Ratio		3.14
Quick Ratio		3.07

Metric
Rule of 40 (LTM)
Rule of 40 (NTM)
Stock Comp to Revenue		0.13
R&D to Revenue		0.58
SG&A to Revenue		0.35