ThalesNano develops and manufactures flow chemistry solutions for chemistry laboratories, aiming to improve the experience of chemists by bringing flow chemistry into daily work practices with fast, safe, and easy-to-use solutions.

ThalesNano

ThalesNano is an innovation-driven company focusing on the development of bench-top flow chemistry instruments and solutions for synthetic chemical challenges.

The company was founded in 2002 in Budapest, Hungary. Since then, ThalesNano operates globally, with the help of our US office and worldwide distributor network.

Currently, more than 1900 of our instruments are used worldwide. Our mission is to make flow chemistry the part of the daily laboratory routine and to make chemical processes safer, easier, and more effective. We put a great emphasis to support research and development by aiding scientific collaborations and education.

Our first instrument on the market, the H-Cube® continuous flow hydrogenation reactor was launched in 2005. The instrument was ground-breaking with its innovative hydrogen generator coupled with the advantages of flow chemistry technology. It has received the R&D Top 100 Award in 2005 and is used in hundreds of laboratories globally. 

Nowadays, the company has the widest portfolio of laboratory-scale instruments for pharmaceutical, biotechnology, fine chemical, flavor and fragrance, agrochemical, and petrochemical markets, as well as for academic research groups and education.

Our family of products solves daily problems with difficult or dangerous reactions. The H-Cube® series instruments have set a new standard for laboratory-scale hydrogenations, by combining on-demand hydrogen generation with continuous flow environment. The Phoenix™ flow systems make chemical processes more effective and significantly safer in an extended chemical parameter window.

In the recent years, our new developments were recognized by the R&D Top 100 Award Committee, awarding the H-Genie® hydrogen generator in 2019, and the PhotoCube™ photoreactor in 2021.

ThalesNano Inc.

Still doing your deuterium labelling in batch, using expensive deuterium gas? In ThalesNano’s H-Cube Pro, you can generate your D2 in situ thanks to the unique and patented cell technology, capable of performing on-demand heavy water electrolysis. The user-friendly interface and many safety features ensure a quick and convenient reaction design with rapid optimization of all parameters. 

Check out the following paper from Fülöp’s group to see how this instrument can be used for deuterations: Mándity, I.M.; Martinek T.A.; Darvas, F.; Fülöp, F.; Tet. Lett.; 2009; 50; 4372-4374 (link: https://lnkd.in/dvikacHT),

or see our application note from our website: https://lnkd.in/dHC95TP6

#thalesnano #hcubepro #reactionoftheweek

Did you know you can replace regular water in our H-Genie with heavy water (D2O)?
Thanks to its innovative design and cell technology, the H-Genie handles this switch effortlessly.
Here’s how:
- Simple Transition: After draining the regular water, you can seamlessly refill with D2O.
- Efficient Purge: Despite a large 3-litre tank, only three washing cycles were needed to reach a deuterium content of 97.5%.
- Prevent Contamination: Submerging a new Water Purifier Cartridge in D2O for one hour ensures proper deuterium exchange in the resin, avoiding contamination once the tank is filled.
- Stability: After overnight air exposure, the deuterium content only dropped by 0.15% per day.
- No Recalibration Needed: The H-Genie continues to accurately regulate deuterium gas flow with no additional adjustments or calibrations required.
Scale up your deuterations with ease using the H-Genie!
Learn more: https://lnkd.in/dDpVk4Wj
#flowchemistry #deuteration

Upgrade Your H-Genie Experience with our Automatic Water Filler! 
Let the instrument work for you:
- monitor the water level and schedule refill cycles when needed,
- check the water quality in the tank, and initiate shutdown then the quality drops below "Millipore Milli-Q" standard.

Say goodbye to the hassle of constantly monitoring your H-Genie's water tank. Enjoy the safety and convenience of unlimited hydrogen generation.

Works with the H-Genie II and H-Genie Lite, as well as the THS System Controller and ReAction Software.
#thalesnano #flowchemistry

💡Excited to have represented ThalesNano Inc. at the recent ACS Publications Symposium: Catalysis for Organic Synthesis in Vienna!⚗️ It was a fantastic opportunity to connect with academic researchers and discuss their research topics.📚 Looking forward to apply what I learned to drive further innovation at ThalesNano!🏆

#ACS #CatalystSymposium #FlowChemistry #Innovation #ThalesNano #Catalysis

🏆 In 2022, the Nobel Prize in Chemistry honored Professors Morten Meldal, Barry Sharpless, and Carolyn Bertozzi for their groundbreaking discovery of click reactions and their impact on bioorthogonal chemistry. 🏆

Among these reactions, the copper-catalyzed alkyne-azide cycloaddition (CuAAC) stands out, especially due to the significant role of triazoles in pharmaceutical chemistry. 💊

We've just published a comprehensive review on how this vital reaction can be seamlessly performed in a H-Cube Pro continuous flow reactor. 

👉 https://lnkd.in/gs4PDUVg

Dive into the paper for all the details, and let us know what other applications you can envision for this reaction in the comments!

🔬 Transform your selective dehalogenations with ThalesNano’s H-Cube Pro continuous flow reactor!

Discover unparalleled convenience and safety with our wide parameter scope and on-demand hydrogen generation. 

Curious about real-world applications? Check out how this innovative technique was used in the synthesis of a Fulvestrant intermediate.

👉 https://lnkd.in/eb_EwK5X

Join the conversation and share your thoughts or experiences with continuous flow reactors in the comments below!

ThalesNano would like to thank the University of Oxford for receiving our 250th H-Cube Mini Plus! We would like to thank you for helping us achieve such a milestone with the system and wish your team the best using it.

Reductive amination is a cornerstone technique for forming secondary amines, vital in synthesizing pharmaceuticals and fine chemicals. With ThalesNano’s H-Cube® Pro, chemists can perform this essential reaction safely and efficiently—no hydrogen cylinders needed! 💡

The H-Cube® Pro generates hydrogen on demand via water electrolysis and comes equipped with pre-filled catalyst cartridges. Say goodbye to handling and filtering catalysts!

Nuzhdin’s group has showcased the remarkable capabilities of the H-Cube® Pro by successfully performing reductive amination on various hydroxymethylfurfural (HMF) derivatives. 📈✨

Curious to learn more? 📄🔍

Check out their 2021 paper for all the details: https://lnkd.in/eiq5hKRK
#Chemistry #Pharmaceuticals #FineChemicals #ReductiveAmination #Innovation #ThalesNano #HCubePro

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