The Column Group (TCG) is a science-driven venture capital firm that makes significant financial and operational commitments to build early stage drug discovery companies based on their unique scientific platforms and potential to deliver multiple breakthrough therapeutics.

TCG’s investment strategy runs counter to the prevailing trend in life sciences venture capital toward assembling diversified portfolios of later stage, single product-orientated companies across multiple industry sectors, with proximity to value inflection points and the early identification of a Pharma “buyer” as key investment considerations.

In contrast, TCG takes the long view in making investments, recognizing that significant time is often required to generate significant value. Our approach is not “building-to-exit.” Key variables, including scientific opportunities, the competitive and regulatory landscape, and Pharma priorities, can change very rapidly. Instead, TCG’s mission is the generation of fundamentally strong companies, built from the ground up based on great science and the ability to generate multiple differentiated product opportunities.

Rather than diversification, TCG emphasizes focus. We are dedicated to early stage drug discovery as the best source of a new generation of novel, highly effective human therapies. We believe that the most critical resources, such as great ideas, world class founders, and top quality managerial and scientific talent, are very rare and that concentrating them within a small cohort of companies is the key path to success.

TCG is about the bold pursuit of big ideas using innovative science to generate breakthrough therapies that address significant diseases. Our firm is committed to all facets of company building and brings together a rich combination of scientific, financial and operational expertise to shape promising science into a value-rich portfolio poised to have a profound impact on human health.

Surrozen

Tenaya Therapeutics

Arcus Biosciences

Gritstone bio

Revolution Medicines

Constellation Pharmaceuticals

Effector Therapeutics

Flexus Biosciences

Rapt Therapeutics

NGM Biopharmaceuticals

Nurix Therapeutics

ORIC Pharmaceuticals

Peloton Therapeutics

PTC Therapeutics

The Column Group

See all job openings posted by The Column Group's portfolio companies on our Careers page!

https://lnkd.in/gtyHpGbq

The Column Group is excited to start recruiting for its newest company Site Therapeutics in partnership with Alex Marson. We are looking for candidates that have experience in functional genomics, immunology, and small molecule drug discovery.

https://lnkd.in/gvEEUfNg

ORIC Pharmaceuticals Reports Fourth Quarter and Full Year 2023 Financial Results and Operational Updates

https://lnkd.in/dp-nzg-n

NGM Bio Provides Recent Business Highlights and Reports Fourth Quarter and Full Year 2023 Financial Results

https://lnkd.in/dGTUNhTB

Nurix Therapeutics Announces U.S. FDA Lifts Partial Clinical Hold on NX-2127 Phase 1 Trial

https://lnkd.in/e_tAsfrH

RAPT Therapeutics Reports Fourth Quarter and Full Year 2023 Financial Results

https://lnkd.in/d9f5mXdn

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The Column Group is a biotechnology investment firm that specializes in providing capital and strategic guidance to startups and early-stage companies in the life sciences sector. The firm focuses on companies developing innovative therapeutics and disruptive technologies that have the potential to significantly impact human health.

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