Tubulis® generates uniquely matched protein-drug conjugates by combining proprietary novel technologies with disease-specific biology. Our goal is to expand the therapeutic potential of antibody drug conjugates (ADCs) ushering in a new era and delivering better outcomes for patients. We will advance a range of conjugates, unlimited by indication, using our own discovery capabilities and by solving development challenges for partners with both antibody and chemical assets.

BioMedPartners

Seventure Partners

High-Tech Grunderfonds

Bayern Kapital

OCCIDENT

coparion

Andera Partners

Evotec

Fund+

Tubulis GmbH

Today we are presenting full preclinical proof-of-concept data for our two lead candidates TUB-040 and TUB-030 at #AACR2024. 
 
Both candidates consist of an IgG1 antibody attached to its payload, the topoisomerase I inhibitor Exatecan, via a cleavable linker system. TUB-030 targets the tumor-associated antigen 5T4, which covers a broad range of solid tumor indications, while TUB-040 targets Napi2b. This antigen is a well-characterized target in ovarian and lung cancer. The two ADC candidates are optimized for long-lasting, durable tumor engagement and minimal off-target toxicity.
 
Our data for TUB-030 and TUB-040 show high and durable anti-tumor efficacy in a range of preclinical models as well as superior results in mouse xenograft models when compared to other ADCs targeting the same antigens. Both candidates also have a high predicted human therapeutic index, and we look forward to initiating the first Phase 1/2a clinical trials in 2024.
 
If you missed the poster presentations, you can read more about our ADC candidates in our press release here: https://bwnews.pr/3JbpKp3 

#AACR2024: Meet our CSO Jonas Helma-Smets, CDO Bjoern Hock, and VP Biology & Translational Research Annette Vogl, in San Diego. Come visit our posters on Monday, April 8, 2022, between 1:30 PM and 5:00 PM PT to hear more about Tubulis’ lead candidates TUB-030 and TUB-040. The posters (2622 & 2623) will showcase comprehensive preclinical proof-of-concept results for both candidates in #solidtumors.
 
More information here: https://bit.ly/3SZ5Nq6 

Today marks a pivotal moment in the evolution of Tubulis. We have successfully closed an upsized and oversubscribed €128 million Series B2 #financing co-led by ​EQT Life Sciences​ and Nextech Invest, with participation from new US-based funds, ​Frazier Life Sciences​ and Deep Track Capital, as well as all of our existing investors.

The support of this syndicate of leading global biotech investors underscores the potential of our unique approach to pioneering the next wave of truly differentiated, disease-specific #ADC therapeutics. With this funding, we are well-positioned to advance our next-generation ADCs into clinical evaluation and achieve clinical proof-of-concept for our lead #SolidTumor candidates, TUB-040 and TUB-030. The proceeds will also support the further development of our technology platforms to unlock novel payloads and the establishment of a US subsidiary to expand our corporate footprint.

We look forward to working with ​Christoph Broja​ and ​Kanishka Pothula​ as new members of our Supervisory Board to realize our vision of providing new, high-quality treatment options for many hard-to-treat #cancers.

Read the full PR here: https://bit.ly/3IxICOZ


We will present preclinical proof-of-concept data for our proprietary lead programs, TUB-030 and TUB-040, targeting #SolidTumors at the upcoming American Association for Cancer Research’s Annual Meeting #AACR24.
Our CSO, Jonas Helma-Smets, our CDO, Bjoern Hock, and our VP Biology & Translational Research, Annette Vogl, will be in San Diego, highlighting the preclinical differentiation of our ADC candidates in two poster presentations on April 8, 2024. Both candidates are characterized by disease-tailored composition and high stability, enabling an exceptionally wide therapeutic window. TUB-030 is directed against the #cancer antigen 5T4, expressed in a wide range of solid tumor indications. TUB-040 targets Napi2b, a well-characterized target in ovarian and lung cancer. Both candidates contain a topoisomerase-I-inhibitor as payload and are optimized for long-lasting, durable tumor engagement and minimal off-target toxicity.
Find more details about the agenda and abstracts in the press release here: https://bit.ly/3SZ5Nq6

Stay tuned to learn more about the full preclinical data, which we will announce in a press release following the presentation at AACR.


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Tubulis is a biotech company with a focus on the development of innovative therapies for cancer and other diseases.

Chief Medical Officer

Vice President, Global Program Head

Associate Group Medical Director, Global Development Team Leader Gazyva / Gazyvaro

Senior PD Medical Director, Global Science Leader

Medical Director Oncology Development

Associate Group Medical Director

Development Manager

Specialist in Hematology&Medical Oncology

Principal Investigator

Head of Laboratory for CLL Pathogenesis

MD PhD Student

Resident in Internal Medicine (Carciology, Pulmology & Nephrology

Chief Medical Officer at Tubulis GmbH

Guenter Fingerle-Rowson

Associate Director Biology

Senior Scientist Cell Biology

Scientist Cell Biology

PhD student

Trainee (Internship and Master's Thesis)

Internship and Research Assistant

Research Assistant

Associate Director Biology at Tubulis GmbH

Saskia Schmitt

Associate Director Bioanalytics

Scientific Manager Bioanalytics

Study Director Bioanalytics

Scientist in vitro Pharmacology

Visiting Research Scientist

Associate Director, Bioanalytics

Felicia Kirschner

Chief Business Officer

Chief Executive Officer

Managing Director

Director Business Development

Project Manager

CBO at Tubulis & CEO at Algiax

Ingo Lehrke

Senior Director - CMC and Bioconjugation

Director, Process and Analytical Development and Manufacturing

Marcus G.

Associate Director Biomarker Development

Biology Lead (Preclinical Lead) in Respiratory

Team Lead in Protein Analytics

Senior Scientist

Researcher

Postdoctoral Scientist

Intern

Student assistant

Expert in translational drug development

Katharina Heinzelmann

Associate Director Quality Control

Associate Director QC and Protein Sciences, Deputy Head QC

Head Of Project Analytics

Sen. Manager Analytics & QC

Head Quality Control Packaging Materials

Manager Quality Control

Dipl.-Ing. Analytics and analyt. Systems

Quality Control Lead

Florian W.

CSO and co-founder

Research Group Leader

Post-Doctoral Scientist

co-founder

CSO and co-founder at Tubulis GmbH

Jonas Helma-Smets

Director QA

Travel

Group Leader QA Compliance & Quality Systems

Group Leader QA GDP

Senior Manager QA GDP

Manager QA

QA Specialist

Judith F.

Associate Director Chemistry

Senior Scientist Bioconjugation and Chemistry

Scientific Advisor

Postdoctoral Research Associate

Doctoral Student

Associate Director Chemistry at Tubulis - Harnessing the power of Antibody-Drug conjugates

Philipp Ochtrop

CEO and co-founder

Geschäftsführer

Group Leader

Scientist

EIT Health LaunchLab

CEO and co-founder at Tubulis GmbH

Dominik Schumacher

Associate Medical Director

Senior Research Fellow

Hematologist

Clinical Program Leader

Clinical Research Fellow

Hematologist | 1st Internal Department - Hematology  | @General University Hospital Prague

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