Tenaya Therapeutics, Inc., a biotechnology company, discovers, develops, and delivers therapies for heart disease in the United States. It develops its products through cellular regeneration, gene therapy, and precision medicine platforms. The company is developing TN-201, an adeno-associated virus (AAV)-based gene therapy to address genetic hypertrophic cardiomyopathy (gHCM) caused by haploinsufficient myosin binding protein C3 (MYBPC3) gene mutations; and TN-301, a small molecule inhibitor of histone deacetylase 6 (HDAC6i) for use in heart failure with preserved ejection fraction (HFpEF) and genetic dilated cardiomyopathy (gDCM). It is also developing TN-401, an AAV-based gene therapy that addresses genetic arrhythmogenic right ventricular cardiomyopathy (gARVC) caused by plakophilin 2 (PKP2) gene mutations; an AAV-based gene therapy designed to deliver the dwarf open reading frame (DWORF) gene in the heart for DCM; and Reprogramming program, an AAV-based approach for cardiac regeneration to replace heart cells lost in patients experiencing heart failure due to prior myocardial infarction. The company was incorporated in 2016 and is headquartered in South San Francisco, California.

Tenaya Therapeutics, Inc.

Tenaya Therapeutics is a clinical stage biotechnology company. The Company was founded in 2016 by leading cardiovascular scientists from the David J. Gladstone Institutes and the University of Texas Southwestern Medical Center.

We are a biotechnology company committed to a bold mission: to discover, design, develop and deliver curative therapies that address the underlying drivers of heart disease. Our vision is to change the treatment paradigm for heart disease, and in doing so improve and extend the lives of millions of individuals and families fighting this debilitating disease. We are advancing a pipeline of disease-modifying therapies developed using our product platforms and core internal capabilities to target defined sub-populations of patients with rare or highly prevalent forms of heart disease.

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T. Rowe Price

RA Capital Management

Tenaya Therapeutics

Wishing safe and happy holidays to our team, our partners, our friends and families and the entire Tenaya community. See you in the new year!

Pioneering the field of genetic medicines for heart disease requires some serious creativity in addition to scientific chops, and this month our Cardiovascular Genetics team showed off their fun side with a mustache-growing contest. Looking good, team. We can't wait to see what you'll do next!

Along with our partners at the DCM Foundation, Tenayans Wendy Borsari, Senior Manager of Patient Advocacy, and Jeff Haroldson, Executive Director of Medical Affairs, will present an informative webinar about genetics, gene therapies and clinical trials for cardiomyopathy today, Dec. 13 from 6:00-7:00 PM ET. 
  
Register here: bit.ly/3QMFCC0  
  
#heartdisease #PatientsFirst #GeneTherapy

Every year before the holidays, we add notes of appreciation to our Tenaya Tree of Thankfulness and watch it grow with the kind words of gratitude we share for each other. This year, we built on our tradition and got together for a special Friendsgiving potluck lunch too. We're thankful to be #OneTenaya!

Today, Tenaya CEO Faraz Ali will participate in a fireside chat at the 35th Annual Piper Sandler Healthcare Conference. Read our press release for more details: https://bit.ly/47OHlxx

Team Tenaya came together in celebration of Diwali, the festival of lights, this month. Our gathering was filled with laughter, good food and great company. Check out these photos of the team! #YouLead #Community #OneTenaya

Curious about the role of gene therapy in cardiomyopathy? We’re partnering with the DCM Foundation to present an informative webinar about genetics, gene therapies and clinical trials for cardiomyopathy on Wednesday, Dec. 13 from 6:00-7:00 PM ET.
 
Wendy Borsari, Senior Manager of Patient Advocacy, and Jeff Haroldson, Executive Director of Medical Affairs, from Tenaya will speak to a range of topics and our hopes for the future of gene therapies for the heart. Click here to register and learn more: bit.ly/3QMFCC0
 
#heartdisease #PatientsFirst #GeneTherapy

Happy Genetic Counselor Awareness Day! Tenaya recognizes the important work genetic counselors do in clinics, labs, hospitals and research to help people better understand their health, make informed healthcare decisions, and shape the future of personalized medicine. Learn more about genetic counselors: https://bit.ly/3Bi7yo8

Yesterday, we announced our Q3 earnings and business highlights - including the receipt of Fast Track designation for TN-401. See below for the top headlines! Read the full press release: https://bit.ly/3ua1mA9 #heartdisease #biotechnews

The latest #OneTenaya G&A #teambuilder brought the group to The Walt Disney Family Museum in San Francisco. The team learned that the journey from the creation of Disney to what it is today holds many parallels to the #biotech industry – there are setbacks, but a common vision and perseverance prevails. 

Thank you to the Museum for hosting us!

	Dec '19	Dec '20	Dec '21	Dec '22	Dec '23
net income	-26.23M -	-38.40M 46.37%	-72.72M 89.40%	-123.67M 70.05%	-124.08M 0.34%
depreciation and amortization	1.99M -	2.48M 24.84%	2.96M 19.25%	6.47M 118.41%	9.00M 39.20%
deferred income tax	-82K -	33K 140.24%	192K 481.82%		3.28M -
stock based compensation	414K -	741K 78.99%	2.95M 298.11%	11.47M 288.71%	15.31M 33.50%
change in working capital	-250K -	-234K 6.40%	4.74M 2,126.50%	-849K 117.90%	-3.28M 286.57%
accounts receivables
inventory
accounts payables	397K -	142K 64.23%	8.60M 5,956.34%	1.66M 80.70%	-3.28M 297.71%
other working capital	-647K -	-376K 41.89%	-3.86M 926.06%	-2.51M 34.97%	3.28M 230.81%
other non cash items	64K -	-75K 217.19%	1.06M 1,518.67%	2.16M 102.63%	-2.30M 206.63%
net cash provided by operating activities	-24.10M -	-35.45M 47.11%	-60.81M 71.56%	-104.42M 71.72%	-102.07M 2.25%
investments in property plant and equipment	-2.93M -	-9.76M 233.66%	-25.12M 157.31%	-20.63M 17.88%	-1.24M 93.99%
acquisitions net	2.66K -
purchases of investments	-12.66M -		-213.44M -	-140.48M 34.19%	-56.64M 59.68%
sales maturities of investments	10M -	2.75M 72.47%		244.75M -	106.62M 56.44%
other investing activites	-2.66K -			8K -	-25K 412.50%
net cash used for investing activites	-5.58M -	-7.01M 25.56%	-238.56M 3,303.20%	83.65M 135.06%	48.72M 41.76%
debt repayment
common stock issued	30.51M -	147.27M 382.63%	188.54M 28.02%	77.39M 58.95%
common stock repurchased	-3K -	-1K 66.67%	-13K 1,200%
dividends paid
other financing activites	30.51K -	147.27K 382.67%	20.44M 13,780.82%	380K 98.14%	4.05M 965.53%
net cash used provided by financing activities	30.51M -	147.27M 382.67%	208.97M 41.90%	77.77M 62.79%	4.05M 94.79%
effect of forex changes on cash
net change in cash	832K -	104.81M 12,497.48%	-90.41M 186.26%	56.99M 163.04%	-49.31M 186.51%
cash at beginning of period	23.44M -	24.27M 3.55%	129.08M 431.84%	38.68M 70.04%	95.67M 147.37%
cash at end of period	24.27M -	129.08M 431.84%	38.68M 70.04%	95.67M 147.37%	46.36M 51.54%
operating cash flow	-24.10M -	-35.45M 47.11%	-60.81M 71.56%	-104.42M 71.72%	-102.07M 2.25%
capital expenditure	-2.93M -	-9.76M 233.66%	-25.12M 157.31%	-20.63M 17.88%	-1.24M 93.99%
free cash flow	-27.02M -	-45.21M 67.31%	-85.93M 90.08%	-125.05M 45.53%	-103.31M 17.39%

NASDAQ:TNYA

Tenaya Therapeutics

Last Close

2.77

30/08 20:00

Market Cap

241.05M

Beta: -

Volume Today

257.84K

Avg: 560.72K

PE Ratio

−2.55

PFCF: −2.80

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