Aravax is a clinical stage biotechnology company developing a novel peptide-based immunotherapy, PVX108, for the treatment of peanut allergy. Aravax is striving to improve the lives of patients living with peanut allergies by developing a therapy that precisely targets the underlying cause of disease, bringing benefits in safety and convenience.

Tenmile

Brandon Capital

Aravax

Thanks to Healio for featuring Aravax’s recently published Phase 1 study from the journal Allergy  EAACI (see comments for a link to the study) in their newsletter.

The key points highlighted for physicians specialising in this space were:
* First-ever peptide-based immunotherapy for food allergies.
* Demonstrated safety with no hypersensitivity or adverse events.
* Clinically relevant immunological changes persisting 18 months after treatment

“PVX108 does not contain the peanut proteins which put patients at risk of serious side effects,” Aravax CSO, Sara Prickett explained to Healio. “Rather, it contains short peptides mimicking key regions from those proteins, which can be used to retrain the immune system to tolerate peanuts but are too small to trigger allergic reactions.”

Phase 2 studies are underway to assess PVX108 in children with peanut allergies. The trial, spanning Australia and the U.S., examines safety and efficacy with 12 doses over 44 weeks.

#MedicalInnovation #FoodAllergyTreatment #PeptideTherapy #ClinicalResearch #AravaxPVX108


Today, we have the pleasure of announcing the successful closing of our US$42 million Series B funding round that will enable us to expand our Phase 2 trial to the United States and accelerate preparations for Phase 3.

Aravax’s lead candidate PVX108 contains synthetic peptides derived from peanut allergens, designed to safely and precisely retrain the immune system to tolerate peanuts.

Results from Phase 1 studies, which showed that PVX108 was well tolerated in peanut-allergic patients and produced clinically relevant changes to peanut immune responses, were recently published in Allergy.

Congratulations to the founders (Profs O'Hehir Robyn, Jenny Rolland, and Dr Sara Prickett) who conducted the original research at Alfred Health and Monash University, and to the Aravax management team who have worked tirelessly to progress the development of PVX108.

Aravax is also grateful for the ongoing support from the Brandon Capital community and Tenmile and welcomes incoming investors Novartis Venture Fund, Breakthrough Victoria, Uniseed and Agati Capital as we pursue our mission to revolutionise the treatment of food allergies.

Yesterday Aravax CSO, Sara Prickett, presented her talk entitled "Targeting T Cells to Treat Food Allergy" to over 150 food allergy research scientists and clinicians from all corners of the world at the 2024 Food Allergy GRC in Ventura Beach, CA. 
 
Sara summarised the scientific rationale for targeting T cells in food allergy, and some of the key immunological data generated to date from studies in peanut-allergic sufferers. Those studies showed that a relatively short course of treatment with PVX108 produced long term, clinically relevant changes in the immune response to peanuts, which is very difficult to achieve with conventional approaches. PVX108 comprises small, synthetic peptides derived from the major peanut allergens which are designed to be incapable of triggering acute allergic reactions.  The data were recently published in
Allergy (https://lnkd.in/dpaXtPnT).
 
It was an excellent meeting, warmly hosted by Stephanie Eisenbarth and Simon Hogan.

Grateful to Forbes Australia for featuring Aravax and sharing our journey towards a safe and convenient peanut allergy vaccination journey thus far.

There has been great interest in our Phase 2 study so far. We have almost completed recruitment of Cohort 1 (adolescents aged 12-17 years old) across 5 trial centers in Australia. Aravax is now preparing to open additional trial centers in the United States for Cohort 2 (children aged 4-11 years old). These are likely to be in the following areas: Atlanta, Baltimore, Boston, Chapel Hill, Little Rock and Los Angeles. Watch this space (or aravax.com.au) for more information, coming soon.

https://lnkd.in/gk7RRhcU

#Aravax #PeanutAllergy #HealthInnovation


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Aravax is a clinical-stage biotechnology company focused on developing and commercializing treatments that harness the body's immune system to prevent and treat diseases. The company's lead product candidate is designed to induce immunological tolerance to treat peanut allergy, a condition affecting millions of people worldwide.

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