Cradle is a biotechnology company that focuses on designing better proteins using machine learning and protein engineering. Their mission is to help replace traditional farms and factories with more sustainable cell-factories that can produce fabrics, food, fuel, and medicines. They offer tools and machine-learning models to make the process of designing cell-factories easier and more efficient.

We believe Cells can theoretically produce almost anything, from fabrics to food, fuel and medicines. Designing cell-factories is hard, but our tools and machine-learning models can make it easier. Our mission is to ultimately help replace traditional farms and factories for a more sustainable world.

Jobs: https://jobs.cradle.bio

Kindred Capital

Index Ventures

Emily Leproust

Feike Sijbesma

John Zimmer

Cradle

🔮 #coolcompany 

Many materials are made using petroleum, which has numerous downsides. iMicrobes is replacing petroleum with methane, sugar and other renewable feedstock to create the same molecules, but with a net-zero or even negative emissions. 

Industrial Microbes has developed a method, using microbes and a fermentation process, that leverages methane, a greenhouse gas 81 times more potent than carbon dioxide, as a primary feedstock in chemical production. By using methane, they can significantly lower both the cost and emissions associated with chemical manufacturing.

Check https://imicrobes.com/ for more.

Every so often we will be highlight a #coolcompany that we hope will succeed, because that will be great for the planet. Follow for more!

📺 How can #AI speed up the time it takes to identify, design and create a transformative biotech product?

Stef van Grieken - Co-founder & CEO of Cradle, and formerly part of the Machine Intelligence and AI team at #Google Research – has a few thoughts on how to reduce barriers to entry, and production, for medicine and synthetic bio products.

🔗 https://hubs.la/Q027jtnF0

TechBio Startups To Watch 👀

"Cradle’s AI fast-tracks innovation in protein engineering. Its software predicts a protein's 3D structure from its sequence and then generates optimised new sequences to meet specified protein design goals, facilitating rapid, repeated protein design and reducing the time and cost of getting a synthetic biology product to market." -- Yara Alenazi, MassMutual Ventures

https://lnkd.in/eP8wciG9

This week in the SynBioBeta Human Health Digest: An exclusive interview with Stef van Grieken, co-founder and CEO of Cradle, a leader in AI and Machine Learning for drug discovery. Read more: https://lnkd.in/e-F2tSsx and subscribe here: https://lnkd.in/eSgBri7X

Europe 🇪🇺 was too late catching the AI waves, and most companies that are or will become the next leaders will be in the United States 🇺🇸 and Asia 🇨🇳 

The United States is investing heavily in biotech startups (1.7x more early stage, 1.4x more late stage). The government are adapting regulation to fit new bio-technologies and investing heavily in bio-technology and bio-manufacturing (including a target to manufacture 30% chemicals with biology and a $2 billion stimulus program)
 
Like with AI, we are at risk of missing this next wave of technological innovation where Europe ends up mostly talking about how we might regulate it, instead of having the market leading companies. I spoke about it with Natasha Lomas from TechCrunch 

We need a European Biotechnology and Biomanufacturing strategy. And fast.

Honoured to be named a 2023 Rising Star ⭐  by investors and founders at Founders Forum Group. 

Each year Founders Forum Rising Stars – early-stage startup founders whose ideas have world-changing potential – are elected by a global network of top founders and investors.

Many of previous founders I admire have been recognised including Demis Hassabis (Deepmind), Luis von Ahn (Duolingo), Taavet Hinrikus (Wise),  Whitney Wolfe Herd (Bumble), and  Payal Kadakia Pujji (ClassPass).

Read more at Founders Forum

https://lnkd.in/gMG85UjU

👀 nominated for the European Lifestars ✨ Awards? 

https://lnkd.in/e3mSZFXS

11 drug discovery startups to watch 👀

"Cradle sits at the intersection of biology and artificial intelligence to change how biologists design proteins. Building new proteins currently takes years of research, but Cradle’s generative machine learning models can predict which parts of a protein’s code a biologist will need to alter and iteratively improve models based on wet lab results. This accelerates the feedback loop, getting results that lead to breakthroughs."

Thank you, Leigh Brody (AlbionVC), Alexander Momeni (General Catalyst), Christian zu Jeddeloh (Norrsken VC) 

🙏 Molecule.one, CellVoyant, CHARM Therapeutics, Isomorphic Labs, Ignota Labs, Turing Biosystems, AQEMIA, Chemify Limited, Multiomic Health, Iktos 

Read more: https://lnkd.in/e2pHQCjV

This week I'll be speaking about 'Large Language Models for Protein Generation' at @BioTechX  

Oct. 4, 15.50, Theatre 12. Come say hi to me and the team 👋

I am glad to share that I recently graduated cum laude with a Master's degree in “Molecular Mechanisms of Disease” at Radboud University! 🎉

Over the past two years, I was fortunate to undertake two exciting internships in the fields of chemical biology and biochemistry. 

In my first internship, I joined the lab of Dr. Kim Bonger at the Institute for Molecules and Materials - Radboud University with the guidance of Kevin Venrooij. I had the opportunity to contribute to the development of a class of universal CAR T cells for the treatment of rheumatoid arthritis and prostate cancer.

I then moved across continents to do my second internship at the lab of Dr. Hidde Ploegh at the Boston Children's Hospital  / Harvard Medical School. With the supervision of Lotte Wijne, we focused on leveraging nanobodies to uncover complex mechanistic roles and explore the translational potential of E2 conjugating enzymes. 

During my academic journey, I had the privilege of meeting incredible friends and doing science with inspiring people from different countries. I am also incredibly grateful for the support and mentorship I've received throughout the program (Dr. Arjan de Brouwer, Dr. Roland Brock, Loes Vaessen, Dr. Helma Pluk, Dr. Annemarie Post).

Now, I am beyond excited to start as a Research Associate for high-throughput experimentation within the bioengineering team at Cradle. I am looking forward to learning more in this role and contributing to the incredible work being done at Cradle.

BIO:CRADLE

Cradle

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