Black Diamond Therapeutics is a biopharmaceutical company focused on developing MasterKey therapies to address broad genetically defined patient populations, overcome resistance, and minimize wild-type mediated toxicities for the treatment of non-small cell lung cancer (NSCLC) and glioblastoma (GBM). The company's mission is to provide people living with cancer the opportunity to experience longer, healthier, and more active lives.

Black Diamond Therapeutics is a clinical-stage oncology company developing MasterKey therapies that target families of oncogenic mutations, expanding the addressable patient population by offering one solution for many mutations. Our mission: defeat cancer resistance and provide people living with cancer the opportunity to experience longer, healthier and more active lives. We are advancing two potent, brain-penetrant clinical-stage programs: BDTX-1535, a fourth-generation EGFR inhibitor targeting non-small cell lung cancer (NSCLC) and glioblastoma (GBM) and BDTX-4933, a RAF inhibitor targeting KRAS, NRAS and BRAF alterations in NSCLC and other solid tumors.

Biotechnology Value Fund

BVF Partners

City Hill Ventures

Wellington Management

Logos Capital

New Enterprise Associates

Invus

Nextech Invest

Roche Venture Fund

Versant Ventures

Perceptive Advisors

Black Diamond Therapeutics

Endpoints' recent coverage of a new survey on the state of the continuously evolving #NSCLC therapeutic landscape reflects progress for the field but still huge unmet need https://lnkd.in/e7AGnJqn. Fewer than one in five oncologists rated the current treatment options as excellent, and the majority are seeking additional treatment options for advanced forms of #cancer, as well as tools to assess biomarkers and other predictive methods that inform treatment efficacy. To learn more about BDTX's unique approach to expand the scope of NSCLC therapies and about its investigational MasterKey drug candidates, visit https://lnkd.in/eWvbfvKc

We expect an exciting year ahead as we continue advancing our clinical programs with the goal of enabling patients to live healthier, longer lives. We anticipate several important BDTX-1535 milestones in 2024, including Phase 2 results for the treatment of #NSCLC, as well as medical meeting presentations of Phase 1 data sets for the treatment of #GBM. We also expect BDTX-4933 Phase 1 results for the treatment of KRASm NSCLC.

Read more: https://lnkd.in/eMiiNsSg

#LungCancer #Glioblastoma

Today we announced topline results from our Phase 1 dose escalation trial in recurrent #GBM, where historical PFS ranges from 2-4 months. BDTX-1535 demonstrated promising clinical activity and more than 1/3 of patients remained on therapy greater than 4 months. These results in heavily pretreated patients are an important first step in understanding the potential of BDTX-1535 to benefit newly-diagnosed GBM patients. We anticipate results from a "window of opportunity" clinical trial of BDTX-1535 in second-line patients with high-grade glioma in 2Q 2024.

Read more: https://lnkd.in/eU7hFh8F

This weekend, Black Diamond will be in the Windy City, joining other pioneers in #oncology at the #IASLC North America Conference on Lung Cancer for robust knowledge exchange and immersion in the latest research as we further advance our pipeline of MasterKey inhibitors for #EGFR, #KRAS and #BRAF driven #NSCLC. 

To learn more about our pipeline, visit: https://lnkd.in/ek2kyjwV

#NACLC23

Lung cancer is the second most common form of cancer in both men and women in the US, according to the American Cancer Society, and November is #LungCancerAwareness Month. The more than 200,000 diagnoses each year inspire, encourage, and empower us every day to relentlessly pursue our mission of developing potentially life changing treatments for patients living with mutated forms of non small cell lung cancer: BDTX-1535 and BDTX-4933. #NSCLC #EGFR #KRAS

To read more about Lung Cancer Awareness Month, visit American Lung Association: https://lnkd.in/dnXYGtR

And to learn more about Black Diamond’s unique approach to targeting families of oncogenic mutations, click here: https://lnkd.in/em4gMAWM

Black Diamond Therapeutics, Inc., a biotechnology company, discover, develops, and commercializes medicines for patient with genetically defined tumors. It develops BDTX-189, an irreversible small molecule inhibitor that is designed to targets oncogenic proteins defined by the non-canonical epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 driver mutations. The company is also developing BDTX-1535, a brain-penetrant inhibitor of EGFR mutations, including canonical, intrinsic resistance, and acquired resistance mutations; and BDTX-4933, a brain-penetrant inhibitor of oncogenic BRAF class I, II and III alterations. It has a strategic partnership with OpenEye Scientific Software, Inc. The company was formerly known as ASET Therapeutics, Inc. and changed its name to Black Diamond Therapeutics, Inc. in January 2018. Black Diamond Therapeutics, Inc. was incorporated in 2014 and is headquartered in Cambridge, Massachusetts.

COM:BLACKDIAMONDTHERAPEUTICS

Black Diamond Therapeutics

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