Sonnet BioTherapeutics Holdings, Inc., a clinical stage oncology-focused biotechnology company, develops platform for biologic medicines of single or bispecific action. The company develops fully human albumin binding technology, which utilizes human single chain antibodies fragment that binds to and hitch-hikes on human serum albumin for transport to target tissues. Its lead candidate is SON-1010, a fully human version of interleukin 12 for the treatment non-small cell lung cancer, and head and neck cancer. The company is also developing SON-080, a fully human version of interleukin 6 for chemotherapy-induced peripheral neuropathy and diabetic peripheral neuropathy. It has a license agreement with New Life Therapeutics PTE, LTD. to develop and commercialize pharmaceutical preparations containing a specific recombinant human interleukin 6. Sonnet BioTherapeutics Holdings, Inc. is based in Princeton, New Jersey.

Sonnet BioTherapeutics Holdings, Inc.

As experts in cytokine biology, our clinical stage pipeline comprises five cytokine-derived therapeutic candidates, with our lead proprietary compound, SON-1010, in Phase 1 development. Closely following are SON-080, in Phase 1b/2a development, and three other candidates undergoing preclinical study.
 
Sonnet’s proprietary FHAB™ (Fully Human Albumin Binding) technology enables the development of innovative targeted biologic drugs with enhanced single- or bi-specific mechanisms. The FHAB™ platform utilizes a fully human single chain antibody fragment (scFv) that binds to and “hitchhikes” on human serum albumin (HSA) for transport to target tissues. Our internal focus is immune oncology, however, we believe our technology is suited for drug development across the spectrum of human disease.
 
Sonnet’s FHAB construct attaches to albumin in the bloodstream, which significantly enhances the pharmacokinetics of the active drug substance. It also naturally accumulates at inflammation sites, including tumors, thereby potentiating delivery to target tissues. Our platform has demonstrated a tenfold increase in half-life and a greater-than-thirtyfold increase in efficacy as compared to recombinant interleukins without FHAB in preclinical studies. We believe the versatile platform can generate a large immune oncology pipeline, including combinations with a variety of biologic drugs. The Sonnet platform is differentiated in that FHAB utilizes a fully human sequence with a human glycosylation profile that can be manufactured using a standard CHO process.


(NASDAQ: SONN)

Sonnet BioTherapeutics, Inc.

We’re excited to announce that we’ve been approved to begin a Phase 1b/2a clinical trial of SON-1010 in combo with Roche's atezolizumab (Tecentriq®) in Australia for patients with platinum-resistant ovarian cancer (PROC).

This combo trial is expected to show proof of concept with SON-1010 for PROC, as well as to augment the foundational work underway with Sonnet’s bifunctional molecules, SON-1210 and SON-1410.

#biotech  #clinicalresearch  #immunotherapy  #cancertreatment 

https://lnkd.in/e2yqAzDg

Today we released our Q1 2023 earnings report, and it’s been an exciting period of progress for our company. Here are some key updates:

•At the American Association for Cancer Research Annual Meeting last month, we released new Phase 1 results for our lead candidate SON-1010 showing its potential as a best-in-class IL-12 cancer immunotherapy. The data reveals our candidate had a prolonged and controlled immune response without causing harmful side effects. And some patients with advanced solid tumors have shown clinical benefit.

•We recently entered into a collaboration agreement with Roche for the clinical evaluation of SON-1010 with atezolizumab (Tecentriq®), a checkpoint inhibitor, to treat patients with ovarian cancer.

•We announced positive results from safety studies of SON-1210 in non-human primates, showing that the drug candidate is safe even at high doses.

•We completed a $15 million financing to support the development of our pipeline and realize the potential of our FHAB (Fully Human Albumin Binding) technology.

To check out our Q1 2023 earnings report, find the link in our press release here: https://lnkd.in/eRC-HnKv

#cancer #immunology #oncology

We are very pleased to unveil our latest data from our lead candidate, SON-1010, showing not only positive safety and tolerability data, but early signs of potential clinical benefit in our cancer patient group. In our healthy volunteer group, SON-1010 exhibited extended pharmacokinetics (PK), which aligns with our preclinical models that show that the candidate drug can persist in the body to produce a therapeutic effect. In addition, in our cancer patient study group SON-1010 showed positive signs of tumor shrinkage. 

We’re thrilled with this progress and the early evidence to support SON-1010 as a best-in-class targeted cancer therapy. 

#cancer #oncology #immunooncology #AACR23

We are excited to share some new updates for our lead clinical candidate, SON-1010: At #AACR23, we’ll be presenting the latest clinical data from SON-1010 in a poster session. Following the session at 5 pm ET, join CMO Richard Kenney and Pankaj Mohan, Ph.D. in a webinar where we discuss highlights from this new data. 

SON-1010 is our first asset showcasing our next-generation Fully Human Albumin Binding (FHAB) platform. It links human interleukin 12 (IL-12) to the FHAB domain. This technology is designed to help improve the delivery and safety of cancer immunotherapies and in pre-clinical mouse models has been shown to reduce tumors by 30-fold compared to IL-12 alone. 

To join our webinar, find login details in the press release here: https://lnkd.in/eYuJPYY4  

#cancer #oncology #immunooncology

We are excited to announce that SON-1210, our leading bifunctional candidate targeting solid tumors, has successfully concluded toxicology studies. This critical milestone enables us to begin regulatory filings during the first half of 2023 for SON-1210 to enter first-in-human clinical trials.

Developed using our Fully Human Albumin Binding (FHAB) technology platform, SON-1210 combines two cytokine drug candidates — human Interleukin 12 and Interleukin 15 — in a single molecule. The FHAB technology is designed to help cancer drugs more safely and effectively target tumors. And as a bifunctional therapeutic candidate, SON-1210 was created to deliver the two cytokines to local tumor tissue, helping to turn “cold” tumors “hot” to activate an anti-cancer immune response. 

To learn more about our recent toxicology studies, visit here. #cancer #oncology #bispecificantibodies http://bit.ly/3jkz4O7

We designed our proprietary Fully Human Albumin Binding (FHAB) platform to overcome some of the major challenges in cytokine-based #immunotherapies. Historically, therapeutic cytokines don’t stay in the body long enough and can have toxic side effects. 

Now we’re excited to announce recent results from our phase 1 dose-escalation study of SON-1010 demonstrating the potential of our FHAB technology to overcome these cytokine delivery challenges in healthy humans. 

The recent PK/PD data shows that SON-1010 has an extended half-life of approximately 112 hours in healthy human volunteers and has an acceptable safety profile. Our technology is designed to be able to use higher doses of cytokines without triggering unacceptable toxicity — thereby activating an immune response to fight tumors. 

We look forward to upcoming collaborations to demonstrate the potential of this powerful cancer therapy. 
#immunotherapy #cancer

For more info on the recent data announcement: 
https://lnkd.in/ewiBkidR

For patients with platinum-resistant ovarian cancer no longer responding to chemotherapy, combination immunotherapies hold great promise. We’re excited to announce a collaboration with Roche to evaluate our lead product, SON-1010, in combination with Roche’s atezolizumab for patients with recurrent ovarian cancer. 

SON-1010 is a proprietary version of the immunotherapy drug interleukin-12 that’s designed to persist in the body longer and target tumors better. Atezolizumab is a commercially approved monoclonal antibody for the treatment of various solid tumor cancers. 

https://lnkd.in/eBYMuCwg

#ovariancancer #immunotherapy #cancer #checkpoint

"In the toughest times, innovation can flourish.” Sonnet’s CEO Pankaj Mohan, Ph.D. shares his perspective on how the biotech industry can keep developing breakthrough medicines in challenging environments.

	Dec '13	Dec '14	Dec '15	Dec '16	Dec '17	Sep '19	Sep '20	Sep '21	Sep '22	Sep '23
revenue	17.50M -		42.40M -	41.70M 1.64%	41.43M 0.65%	40.61M 1.98%		483.63K -	349.94K 27.64%	147.81K 57.76%
cost of revenue			14.04M -	13.39M 4.59%	13.69M 2.25%	7.93M 42.06%
gross profit	17.50M -		28.36M -	28.31M 0.18%	27.74M 2.01%	32.68M 17.81%		483.63K -	349.94K 27.64%	147.81K 57.76%
selling and marketing expenses
general and administrative expenses			7.42M -	5.80M 21.77%	4.55M 21.64%	2.51M 44.80%	7.53M 200.26%	8.94M 18.62%	8.58M 4.04%	7.13M 16.90%
selling general and administrative expenses			7.42M -	5.80M 21.77%	4.55M 21.64%	2.51M 44.80%	7.53M 200.26%	8.94M 18.62%	8.58M 4.04%	7.13M 16.90%
research and development expenses						2.20M -	9.88M 349.12%	16.63M 68.41%	21.44M 28.91%	11.81M 44.90%
other expenses	-23.29M -		3.36M -	3.45M 2.53%	5.19M 50.59%	11.05M 112.82%		125.50K -
cost and expenses	-23.29M -		24.82M -	22.64M 8.76%	23.43M 3.49%	4.71M 79.91%	17.41M 269.80%	25.57M 46.86%	30.02M 17.40%	18.94M 36.91%
operating expenses	-23.29M -		10.78M -	9.25M 14.19%	9.74M 5.29%	4.71M 51.66%	17.41M 269.80%	25.57M 46.86%	30.02M 17.40%	18.94M 36.91%
interest expense			-3.47M -	-2.35M 32.37%	-2.59M 10.48%	-2.53M 2.53%	20.68K 100.82%		-40.77K -
ebitda	-5.80M -		-13.43M -	-9.28M 30.90%	-6.46M 30.39%	-4.71M 27.12%	-10.54M 123.79%	-24.97M 136.98%	-29.62M 18.61%	-18.68M 36.94%
operating income	-5.80M -		-11.49M -	-2.62M 77.19%	-5.24M 99.83%	-4.71M 10.07%	-24.24M 414.78%	-25.09M 3.51%	-29.67M 18.26%	-18.79M 36.66%
depreciation and amortization			2.36M -	2.34M 0.98%	2.28M 2.52%	2.16M 5.22%	13.70M 533.25%	117.20K 99.14%	52.48K 55.22%	75.75K 44.34%
total other income expenses net	-165.36K -		-2.83M -	-1.53M 46.09%	-2.58M 68.57%	-162.87K 93.68%	-27.34K 83.21%	103.47K 478.43%	-52.48K 150.72%	-40.08K 23.64%
income before tax	-5.96M -		-14.32M -	-4.15M 71.04%	-7.81M 88.32%	-4.87M 37.63%	-24.27M 398.13%	-24.98M 2.96%	-29.72M 18.96%	-18.83M 36.64%
income tax expense			-187.57K -	-198.46K 5.81%	644.43K 424.71%	162.87K 74.73%	6.80M 4,072.28%	22.03K 99.68%	52.48K 138.27%	40.08K 23.64%
net income	-5.96M -		-12.14M -	-9.08M 25.21%	-6.79M 25.14%	-5.03M 25.91%	-31.06M 517.01%	-25.01M 19.49%	-29.77M 19.07%	-18.83M 36.75%
weighted average shs out	4.37M -		14.25M -	21.70M 52.29%	2.53M 88.36%	382.01K 84.87%	672.89K 76.14%	1.75M 160.57%	4.35M 147.99%	1.04M 76.12%
weighted average shs out dil	4.37M -		14.25M -	21.70M 52.29%	2.53M 88.36%	382.01K 84.87%	672.89K 76.14%	1.75M 160.57%	4.35M 147.99%	1.04M 76.12%
eps	-1.37 -	0 100%	-0.85 Infinity%	-0.42 50.59%	-2.69 540.48%	-13.18 389.96%	-46.16 250.23%	-14.26 69.11%	-6.85 51.96%	0 100%
epsdiluted	-1.37 -	0 100%	-0.85 Infinity%	-0.42 50.59%	-2.69 540.48%	-13.18 389.96%	-46.16 250.23%	-14.26 69.11%	-6.85 51.96%	0 100%

COM:SONNETBIO

Sonnet BioTherapeutics Holdings, Inc.

Last Close

2.89

22/11 21:00

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