TissUse GmbH has developed a proprietary human-on-a-chip technology platform to accelerate the development of pharmaceuticals, providing products that simulate human organ activity and offering custom solutions for the evaluation of drugs, cosmetics, and chemicals.

TissUse GmbH

TissUse GmbH | 7,215 followers on LinkedIn. Emulating Human Biology | TissUse is a Berlin, Germany-based, biotechnology company, which has developed a unique “Multi-Organ-Chip” platform that provides unparalleled preclinical insight on a systemic level using human tissues. This enabling technology platform consists of a miniaturized construct that closely simulates the activity of multiple human organs in their true physiological context. TissUse’s Multi-Organ-Chips provide a new approach to predict, for example, toxicity, ADME profiles and efficacy in vitro, reducing and replacing laboratory animal testing and streamlining human clinical trials.

Senior Scientist at TissUse GmbH

Eva-Maria Dehne

Business Development | Research Scientist | Science partnerships

Vignesh Viswanathan

CEO at TissUse GmbH

Reyk Horland

Ilka Maschmeyer

🔴 TissUse at Falling Walls Summit 2024! Round Table discussion about "Overcoming Animal Testing with Advanced Cell Models." At Falling Walls’24, our visionary founder Prof. Dr. Uwe Marx shared insights on our cutting-edge multi-organ chip technology, which mimics the complex interactions between human organs, providing more accurate, human-relevant models for drug testing, toxicity screening, and disease modeling. Do not miss out Prof. Marx’s vision for the future of biomedical research and the regulatory challenges to realizing organoids as reliable alternatives to animal testing. Simply click on the link below to access the full video and discover more about our participation in this landmark event! 🔗 Watch the full video: https://lnkd.in/epMCcS2E Panel include between 1:28:37 and 1:35:55: Seyoum Ayehunie (MatTek, US), Uwe Marx (TissUse, DE), Martha Mayo (Sartorius, US), Zaher Nahle (The Ivyctory Group, US), Alison Abbott (Moderator) (Freelance Journalist, DE). #FallingWalls #Innovation #MultiOrganChips #AlternativesToAnimalTesting #DrugDevelopment #EthicalResearch #FutureOfScience

🚀 TissUse GmbH Expands Horizons in Korea! 🌍 Our visionary founder, Uwe Marx, recently gave an insightful interview with Science 조선비즈 CHOSUNBIZ , showcasing TissUse GmbH ’s pioneering work in #organ -on-a-chip technology and our ambitious strides in international collaboration! 🧬✨ Key Takeaways: - Organ chips: transforming drug safety and efficacy testing and paving the way for personalized patient treatments. - Ongoing collaborations with global regulators and leading pharmaceutical companies to gain regulatory approval by 2026. - Strategic cooperation with Osong 3D Biological Tissue Chip Demonstration and Commercialization Support Center (OK-MPS), positioning Korea as a key player in advancing and validating long-term chip technology. - Uwe Marx highlighted Korea’s potential as "10 times greater than Europe," attributing it to cutting-edge research capabilities and a strong infrastructure for medical innovation. 🔗 For an in-depth look, check out the full article on Science Chosun 조선비즈 CHOSUNBIZ ! 📰 (Note: The article is in Korean, so don't forget to translate! 🌐) https://lnkd.in/etznxbYw We’re proud to work alongside world-class institutions, accelerating breakthroughs in microphysiological systems (MPS) and advancing the future of healthcare. 🌱💡 #NAMs #OrganOnAChip #AnimalTestingAlternatives #Koreagermany

What if we could accurately simulate drug absorption and toxicity using a microphysiological system ( #MPS )? In an exciting new study, researchers from the Chinese Academy of Medical Sciences & Peking Union Medical College and TissUse GmbH (Berlin) have developed an intestinal-liver-on-chip model to evaluate hepatotoxicity after an acetaminophen (APAP) overdose. This innovative approach mimics drug absorption and metabolism, overcoming limitations seen in traditional animal models for drug safety evaluation. Hepatotoxic assessment in a micro physiological system: Simulation of the drug absorption and #toxic process after an overdosed acetaminophen on #intestinal -liver-on-chip Using Caco-2 and HT29-MTX-E12 cells to establish intestinal equivalents and HepG2, HUVEC-T1, PMA-induced THP-1, and hepatic stellate cells for liver equivalents, the study effectively simulated acute #liver injury post-APAP overdose. High-performance liquid chromatography was used to track APAP concentration, and various liver injury biomarkers, including aspartate aminotransferase (AST) and alanine aminotransferase (ALT), were monitored over 4 days, showing stable and reliable results. This #organ -on-chip model not only enhances our understanding of toxicokinetics but also provides a valuable tool for drug toxicity assays. The findings could further open doors for safer drug development with fewer animal models. Interested in how TissUse GmbH is pushing the boundaries of #MPS microphysiological systems for drug safety evaluation? Discover more about how we’re using cutting-edge organs-on-chips to model complex biological processes and predict toxic effects. Visit our website to learn more: https://lnkd.in/ey-8mxrP Read the full article here: https://lnkd.in/eAiqrmgC #OoC #MPS #hepatotoxicity #DILI #microphysiologicalsystems #tox #drugdevelopment

We’re excited to have contributed our insights to the remarkable article in Johns Hopkins Magazine titled „Animal Research: Reimagining Alternatives to Animal Testing." The key message is that shifting away from animal testing isn't just about ethics—it's about the efficiency of alternatives. With data showing a potential 26% reduction in R&D costs and the integration of AI with new methods, we can drive even more progress. We're proud TissUse GmbH to be part of this moment championing cutting-edge NAMs. The FDA Modernization Act 2.0 is set to be as monumental as its 1938 predecessor, paving the way for safer, more efficient science. We agree with Thomas Hartung view "it is time to complement and then to replace the animal tests where we can do better" Curious to read the article? https://lnkd.in/gmiwT_Xt #NAMS #TissUse #OrganOnAChip #BiotechInnovation #Multi -OoC

📢 ALTEX Publication Award 2023 🏆 Coming back from the EUSAAT conference in Linz, I am excited to share that our article "A microfluidic thyroid-liver platform to assess chemical safety in humans" was rewarded with the ALTEX publication award 2023. It is truly a great milestone and underlines the impact of our collaborative work. A huge thanks to all the team members who made this possible: Dr. Diana Karwelat , Helen Tinwell , Sophie Rigal , Remi Bars , Marian Raschke , Thomas Steger-Hartmann , Özlem Vural & Uwe Marx. I am thrilled to further work in this stimulating field and push the thyroid-liver coculture approach into application at Bayer CS and to further contribute to our internal NAMs strategy. ➡ Curious to read the publication? https://lnkd.in/ew6YvsBj TissUse GmbH #ALTEX #LSC #InnovationAtBayer #teambayer #MPS https://lnkd.in/ehDz_AR4

Julia Kühnlenz

It was a great pleasure to welcome the jGBM Berlin team in our office and introduce our “Human-On-A-Chip” technology. Sharing how our platform supports drug development while reducing animal testing made for a great exchange of ideas. Looking forward to sharing more exciting updates soon! #TissUse #jGBM #BioTech #MicrophysiologicalSystems #OrgansOnChip

We are thrilled to share our latest groundbreaking research with amazing collaborators from AstraZeneca and Linköping University —successfully replicating human glucose regulation in vitro using a pancreas-liver chip! This platform mimics the key interactions between these organs, enabling us to study glucocorticoid-induced diabetes while integrating mathematical modelling. Our results are reproducible across labs, giving us confidence that this model will unlock new therapeutic targets and transform drug discovery in metabolic disease research 🎯

After that, visit our booth (Number 513), conveniently located next to the beverage area, to discuss your Kidney-on-Chip or other MPS needs in detail. Take pictures of our HUMIMIC lab. #TissUse #ISSCR #ooc

🌟 We’re very excited to be a part of the ISSCR 2024 Conference in Hamburg, exploring the latest innovations and presentations in the stem cell research community and how building up complex organ systems and disease models for drug testing in our microphysiological systems platform. 📍 Our Booth: Meet our team members at Booth #513: Beren Ataç Wagegg , Rosanna Stolberg , and Vignesh Viswanathan . Learn about our innovative technology or catch up since our last conversation. They look forward to meeting you in person! 📋 Poster Sessions: Rosanna Stolberg : Poster Board Number 313, presenting "Towards Immunity on Chip - Immune Cell Perfusion of An iPSC-derived Intestinal Model” on Wednesday, July 10, at 5:45 PM. Beren Ataç Wagegg : Poster Board Number 430, presenting "iPSC-derived Proximal Tubule-like Cell Maturation in ADME-Chip for Toxicity Testing" on Wednesday July 10 – 6:45 PM. Let us know if you will be there—we are looking forward to meeting you and exploring how we can drive scientific research forward together. #ISSCR2024 #StemCellResearch #Organoids #MicrophysiologicalSystems #Innovation #ScientificConference

🌟 Excited to be at EUROoCS2024 in Milan! 🌟 We're thrilled to be exhibiting at the EUROoCS2024 Conference in Milan, and look forward to hearing all the new developments and talks in the organ-on-chip field. 👥 Visit Our Booth: Connect with our team, Ilka Maschmeyer and Vignesh Viswanathan , for an introduction to our cutting-edge technology or an update since your last meeting. Discover how our advancements can support your research and development needs. 🔬 Don’t Miss These Highlights from our collaborators: - Talk by Andrew Morrison: Development of a perfused vascularised lymph node-on-chip (Session 2A: Immune System, 12:10 - 12:30, 3rd July). - Poster Presentation by Jonas J. : Poster ID T-014, showcasing a characterization of the Vascularised-Chip during the Thursday poster session. Looking forward to exploring the latest innovations and discussing how we can advance scientific research together. #EUROoCS2024 #OrgansOnChip #MicrophysiologicalSystems #Biotech #Innovation #ScientificConference

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